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Association of -592 Region of IL-10 Polymorphisms with Asthma in South-Eastern Iranian Patients by Elham Hakimizadeh, Mohammad Kazemi Arababadi, Gholamhossein Hassanshahi, Behzad Nasiri Ahmadabadi, Hamid Hakimi, Mohsen Rezaeian, Vajihe Akbarpour Salehabadi, Hassan Yousefidaredor, Hamid Abousaidi, Derek Kennedy

Background: Cytokines are considered important factors for the pathogenesis of asthma as they play a key role in the regulation of immune responses. The aim of this study was to investigate the association between this disease and polymorphisms in the -592 region of the IL-10 gene.
Methods: This study was carried out on 100 asthmatic patients and 100 healthy controls. PCR-RFLP was applied to examine the polymorphisms in the -592 region of the IL-10 gene.
Results: Our results showed a significant difference between patients and controls in terms of genotypes and alleles of the -592 region of the IL-10 gene.
Conclusions: According to our results, it can be concluded that the IL-10 promoter polymorphisms may play a crucial role in the pathogenesis of asthma.

DOI: Clin. Lab. 2012;58:267-271