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High Copper and Low Zinc Serum Levels in Iranian Patients with Multiple Sclerosis: A Case Control Study by Ali Ghazavi, Saeed Kianbakht, Keyvan Ghasami, Ghasem Mosayebi

Background: The purpose of this study was to evaluate the levels of zinc (Zn) and copper (Cu) in the serum of Iranian patients with multiple sclerosis (MS).
Methods: The serum levels of zinc (Zn) and copper (Cu) were measured in sixty Iranian patients with MS and compared with sixty age-, gender- and socioeconomic status-matched healthy subjects without any neurological disorders as controls from the same geographical area.
Results: Significantly lower serum Zn and higher serum Cu levels were found in the MS patients compared with the controls (p<0.0001 and p=0.002, respectively). The serum Zn level of the secondary-progressive MS patients was significantly lower compared with the relapsing-remitting MS patients (p=0.009). There was no significant difference between the serum Cu levels of the two subgroup of MS patients (p=0.42).
Conclusions: The results suggest significant deviations of the Iranian MS patients' serum Zn and Cu levels from the norm.

DOI: Clin. Lab. 2012;58:161-164