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Clinical Significance of Serum CA125 in Nephrotic Syndrome by Tao Peng, Ling Guo, Qing Xia, Xiangdong Yang

Background: To investigate the clinical significance of serum CA125 in the patients with nephrotic syndrome (NS).
Methods: Three hundred and twenty-two patients with NS and 120 healthy volunteers were enrolled in our study. We measured serum CA125 and analyzed the probable relationship between elevated CA-125 levels in patients with NS, with and without ascites. Ascites were determined by B-mode ultrasonography in patients with NS.
Results: Serum CA-125 in NS patients with ascites was significantly increased compared to NS patients without ascites (p<0.05). There was no statistically significant difference between the healthy volunteers and the patients without ascites (p>0.05).
Conclusions: Serum CA125 is a useful index in the diagnosis of ultrasonographically detected ascites in patients with NS.

DOI: Clin. Lab. 2012;58:113-115