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Automated Immunoassay for Reliable Measurement of Sex Hormone Binding Globulin (SHBG) by D. Gruson, D. Maisin, C. Fillee

Background: Sex hormone binding globulin (SHBG) is important for the transport and regulation of distribution of sex steroids.
Methods: The performance of the Architect® SHBG automated immunoassay in comparison to radioimmunoassay was evaluated using 62 patient specimens. Furthermore, specimen from 100 healthy individuals were used to establish a preliminary reference interval for this automated assay.
Results: The assay has demonstrated overall good analytical performance and was significantly correlated with the reference method.
Conclusions: The Architect ® SHBG assay is a good method for routine measurement of SHBG circulating levels.

DOI: Clin. Lab. 2011;57:87-90