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Abstract |
Acute Inflammatory Biomarkers in Cerebrospinal Fluid as Indicators of Blood Cerebrospinal Fluid Barrier Damage in Japanese Subjects with Infectious Meningitis |
Background: The blood-cerebrospinal fluid barrier (BCB) has selectivity for protein components with different molecular weights. Protein components in the cerebrospinal fluid (CSF) change when the BCB is damaged. We calculated the α2 macroglobulin (α2M) index as an indicator of BCB permeability from the point of view of molecular weight and evaluated the relationship between the α2M index and CSF concentrations of the inflammatory biomarkers interleukin-6 (IL-6), C-reactive protein (CRP), and serum amyloid A (SAA) in Japanese subjects with infectious meningitis, in order to determine the clinical significance of those inflammatory biomarkers in CSF.
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