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Non-Infectious Transfusion.Associated Reactions - Results of Retrospective Investigations Performed in a National Blood Transfusion Service between 1994 and 1996 Including the Results of the Investigations for Bacterial Contamination by Petra Michel, Birgit Lucke, Cornelie Lonicer, Wilhelm Weise

From 1994 to 1996 we retrospectively investigated 917 cases of reported possible transfusion-associated noninfectious reactions involving 1123 blood products. In most cases the observed symptoms were not severe. Nevertheless, hemolysis was reported in 0.5%, anuria in 0.4%, icterus in 1% and shock in 6% of the cases. By retrospective investigation we found 2 cases (0.2%) of AB0 incompatibility caused by clerical error and 21 cases (2.3%) of unexpected antibodies against donor red blood cells reacting in vitro at 37°C or with AHG. No bacterial contamination was found. In more than half of the cases from 1995/96 we found HLA and/or thrombocyte antibodies. There was no possibility to draw a conclusion from the reported symptoms to the existence of relevant medical findings by the serological investigations.

DOI: Clin. Lab.1999;45:631-638