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Comparison of Monoclonal Anti-A- and Anti-B-Reagents with Monoclonal Anti-AB-Reagents by Erwin Strobel

Since 12.1996 the German guidelines for blood group typing stipulate the obligatory use of monoclonal anti-A and anti-B reagents, but no longer that of an anti-AB reagent. By titration we therefore compared commercially available monoclonal anti-A and anti-B reagents of ten manufacturers with the monoclonal anti-AB of the same manufacturers. The mean values of the monoclonal anti-AB reagents were only 1/2 geometrical titer step stronger than the corresponding anti-A and showed nearly the same titer as the corresponding anti-B reagents, so that we found no reason for continuing the use of monoclonal anti-AB reagents. Since there were some distinct differences between several manufacturers, the quality control of the reagents is still of great importance

DOI: Clin. Lab. 1999;45:603-608