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Abstract |
Pre-analytical Aspects of Lipoprotein Measurement |
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Pre-analytical inconsistencies and errors in lipoprotein measurement are often a problem for correct risk stratification and therapeutic intervention in disorders of lipid metabolism and cardiovascular disease. Preanalytical errors can account for up to 80% of the total analytical error of a laboratory result. Knowledge of the intraindividual biological variation, which can account for up to 90% of the total intraindividual variation of a lipid finding, is particularly important. Added to this are behavioral influences such as diet, obesity, alcohol intake, smoking and exercise. Clinical sources of variation include medications, illnesses such as acute myocardial infarction, subacute and acute inflammatory disease, secondary illnesses with altered metabolism and weight changes. Further important factors are the manner of specimen collection and chemical and physical influences on the specimen material. Direct analytical sources of variation are endogenous interferences such as hemolysis, hyperbilirubinemia, lipemia and also anticoagulants. Only the knowledge and evaluation of all pre-analytical sources of variation can determine whether an analytical result has the signifîcance of a pathological sign and thus indicates a disturbance of lipoprotein metabolism as a risk factor for cardiovascular disease |
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