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Evaluation of the Reference Range for Soluble Interleukin-2 Receptor (sIL2R) in Serum with Respect to Age and Gender related Differences: Inadequency of Blood Donors as a Control Population by René Gottschalk, Jan Gossmann, Albrecht Falkenbach, Rainer Wigand

We compared the serum levels of soluble interleukin-2 receptor (sIL2R) in a group of blood donors with the range of serum sIL2R concentration in a large group of well characterized healthy individuals. The healthy controls underwent a thorough clinical and laboratory examination before recruitment, exclusion criteria were acute or chronic illnesses and atopy. This resulted in a cohort of 183 healthy individuals (HI) compared to 72 blood donors (BD). sIL2R was determined by an ELISA. The arithmetic mean ± 2 SD was defined as normal limits. The BD's range was 145.2 - 891.2 (518.2 ± 186.5) U/ml, whereas the HI's normal range was 134.8 - 417.2 (276.0 ± 70.6) U/ml. The difference was highly (p<0.00001) significant. No significant age and gender related differences could be found among the HI. Therefore we conclude that blood donors are probably not suitable for determining a normal range for sIL2R serum concentrations.

DOI: Clin. Lab.1999;45:59-64