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Chemiluminescence Immunometric Assay for Measuring Osteocalcin in Healthy Children by Oliver Fricke, Angelika Stabrey, Eckhard Schoenau

Osteocalcin (OC) was measured in serum samples from 92 children and adolescents (57 females, 35 males) by a two-site chemiluminescence immunometric assay (Nichols Institute Diagnostics, USA), which recognizes the 1 - 19 region of the whole molecule as well as the large N-terminal midregion fragment representing the main part of OC in serum. The highest OC levels are measured between the age of 10 - 15 years. The linear correlations between OC and alkaline phosphatase were 0.65 (p < 0.01) for total alkaline phosphatase (TAP) and 0.61 (p < 0.01) for bone alkaline phosphatase (BAP).

DOI: Clin. Lab. 2000;46:281-284