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Background: The detection of D-dimer is easily affected by interfering substances, causing a false increase in D-dimer levels and leading to incorrect diagnosis and treatment of diseases in clinical practice. Therefore, correcting interference and obtaining true D-dimer results is crucial.
Methods: Gradient dilution test, parallel test with different detection systems, and detection after sample pretreatment with dithiothreitol (DTT) were used to evaluate and correct interference.
Results: The dilution test indicated the presence of detection interference. The Stago detection system shows that the level of D-dimer had dropped to the normal range. After DTT treatment, the D-dimer level of the sample decreased to 0.18 mg/L, consistent with the Stago detection system.
Conclusions: When a patient's D-dimer levels are abnormally elevated but there are no relevant clinical manifestations, the presence of detection interference should be considered. Preprocessing samples with DTT may be a simple and feasible solution to eliminate interference.
DOI: 10.7754/Clin.Lab.2025.250313
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