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Background: Auer rods are considered to be a distinctive feature of acute myeloid leukemia, presenting in the cytoplasm of leukocytes in a purplish-red rod-like, wood-bundles-like, and spindle-like morphology. In this paper, we report a rare presence of wood-bundles-like Auer rods in the plasma cells of patient with multiple myeloma (MM).
Methods: Retrospective analysis of the clinical presentation and laboratory diagnosis of patients with multiple myeloma containing Auer rod-like inclusions in plasma cells were reviewed in this study.
Results: In 2014, 15% of plasma cells were shown in the patient's bone marrow smear, and the diagnosis of multiple myeloma was considered. The cytosol of plasma cells was medium-sized, the nucleus was deviated, the chromatin was aggregated in clumps, and Auer rod-like inclusions arranged in woody bundles were seen in the cytoplasm. In 2017, the patient's condition relapsed, and an abnormal increase of κ-type free light chains was found in the urine, and the urine Bence-Jones protein was positive. In 2021, the patient's condition aggravated to the point of death.
Conclusions: In this uncommon case, the source and mechanism of Auer rod-like inclusions production should be paid more attention to provide rational suggestions for clinical diagnosis.
DOI: 10.7754/Clin.Lab.2024.241049
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