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Background: Here we present a rare case of anti-Kpa alloantibody identified in a Chinese individual, along with a literature review.
Methods: An antibody identification test was conducted to clarify the antibody specificity. To further characterize this antibody, we assessed the reactivity of the patient's serum with relative antigen-positive red blood cells at different test phases. We also investigated the sensitivity of the antigen to DTT and papain. We separated the pa-tient's own RBCs from the transfused ones using capillary centrifugation and performed direct antiglobulin test and Kell blood group antigen detection.
Results: The patient's Kell phenotype was Kp(a-b+), and an IgG-specific anti-Kpa antibody was identified, resulting from the transfusion of Kp(a+b+) allogeneic red blood cells (RBCs). The Kpa antigen on RBCs was susceptible to 0.2M DTT but not to papain.
Conclusions: This case highlights the presence of an anti-Kpa antibody in the Chinese population, suggesting that a reassessment of the frequency of this antigen in this demographic is warranted.
DOI: 10.7754/Clin.Lab.2025.250212
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