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Background: This study aimed to investigate the predictive value of D-dimer (D-D) and prothrombin time for severity and adverse cardiovascular events in patients with acute myocardial infarction (AMI).
Methods: A total of 314 patients who were diagnosed with AMI and underwent percutaneous coronary intervention (PCI) in the Department of Cardiology, Linquan People's Hospital, from January 2020 to December 2023 were selected. According to Killip classification, patients were divided into severe and non-severe AMI groups. Within 2 hours after admission, 3 mL of cubital venous blood were drawn for blood biochemical and coagulation tests. According to the patient's electrocardiogram, coronary angiography, and other tests, the diagnosis of acute myocardial infarction was confirmed.
Results: D-D and prothrombin time (PT) in the severe group were significantly higher than those in the non-severe group, and the difference was statistically significant (p < 0.05). The number of patients with PCI of left circumflex artery, right coronary artery stent implantation, single and double stent implantation in the severe group was higher than that in the non-severe group, and the results were statistically significant (p < 0.05). The results of ROC curve showed that the area under the curve, sensitivity, and specificity of D-D and PT were significantly better than those of cardiac troponin T(cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with severe myocardial infarction (p < 0.05). In addition, the results of bivariate regression analysis showed that D-D and PT were significantly correlated with Killip classification (p < 0.05). Multivariate logistic regression analysis showed that previous history of heart failure, left ventricular ejection fraction, PT, and D-D were independent risk factors for adverse cardiovascular events in patients with AMI (p < 0.05).
Conclusions: Serum D-D and PT have important predictive value for adverse cardiovascular events in patients with AMI.
DOI: 10.7754/Clin.Lab.2024.240941
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