Abstract
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Cellular War: The Dominance Struggle of Polycythemia Vera and Chronic Lymphocytic Leukemia Clones Within a Patient
by Pusem Patir, Firdevs P. Eskin, Gozde Ilhan, Sinem E. P. Unal, Sena U. Coskuner, Dinc Suren, Erdal Kurtoglu
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Background: Polycythemia vera (PV) and chronic lymphocytic leukemia (CLL) are distinct hematological malignancies. While their coexistence is rare, it poses unique diagnostic and therapeutic challenges.
Methods: A 50-year-old male patient presented with elevated hemoglobin levels and a marked lymphocytosis. Diagnostic investigations revealed the presence of both PV and CLL. The patient received treatment for PV followed by CLL.
Results: Initial treatment with hydroxyurea for PV led to progression of CLL. Subsequent treatment with rituximab and venetoclax effectively managed CLL, although the JAK2V617F mutation re-emerged.
Conclusions: This case highlights the potential for independent origins of myeloid and lymphoid neoplasms. Further research is needed to understand the interplay between these two malignancies and optimize their management.
DOI: 10.7754/Clin.Lab.2024.240925
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