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AML with RUNX1::RUNX1T1 Cooperating two Mutations Relapsed Quickly after Achieving CR by XinhongYang, Yingwei Wu, Xiaofeng Yang, Xue Wu, Yingying Chen, Rongjuan Zhang, Zhihua Zhang

Background: Acute myeloid leukemia (AML) with t(8;21)(q22;q22.1); RUNX1::RUNX1T1 has a relatively favorable prognosis with a high complete remission rate and long disease-free survival.
Methods and Results: Here we describe a patient who had AML with t(8;21)(q22;q22.1); RUNX1::RUNX1T1. Cooperating mutations including KRAS and ASXL1, and with other abnormal karyotype del(17) and with a myelomonocytic differentiation.
Conclusions: The patient relapsed despite achieving a morphologic complete remission (CR).

DOI: 10.7754/Clin.Lab.2023.230923