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Lamotrigine-Induced Hemophagocytic Lymphohistiocytosis with DRESS by Hong Wang, Jing Peng, Wenbin Zeng, Xueyi Pan

Background: Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory reaction syndrome caused by genetic or acquired immune dysregulation. The majority of adult HLH cases are caused by tumors, rheumatic immune disorders, and infections. However, drug-induced HLH is rarely reported.
Methods: We report a case of HLH in an adult caused by the administration of lamotrigine, to our knowledge, only nine other cases of lamotrigine-associated HLH have been reported in adult patients.
Results: After discontinuing lamotrigine and using steroid hormones for the HLH, the patient's condition has been brought under control.
Conclusions: This case confirms that dexamethasone is also effective for drug-induced HLH. Usually, after discontinuing the relevant medications, there is no need for further maintenance treatment.

DOI: 10.7754/Clin.Lab.2023.230730