ISSN 1433-6510
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vol
70
11/2024
vol
70
12/2024
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Abstract

 DNA Marker in Stool Led to a Second High-Quality Colonoscopy Within Three Months and Removal of an Undetected High-Risk Polyp by Susanne Franck, Moritz Eidens, Jürgen Fuhrländer, Dagfinn Ogreid

Background: In this case study, the patient first had a colonoscopy based on an incidental episode of vomiting and abdominal pain.
Materials and Methods: Two months after recovery, a multitarget stool test (ColoAlert®) was performed and showed a known somatic mutation in the oncogene KRAS, reported to be associated with colorectal cancer. As a result, a second complete colonoscopy was performed at another center.
Results: This procedure led to the diagnosis and removal of a later classified high-risk polyp that had been missed during the initial colonoscopy.
Conclusions: This case report shows the use of genetic markers in stool testing has the potential to detect colon cancer in very early stages when treatment is inexpensive and effective.

DOI: 10.7754/Clin.Lab.2023.230716