Abstract
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M-Type Phospholipase A2 Receptor Autoantibody Measured by ELISA has Diagnostic Value in Patients with Idiopathic Membranous Nephropathy
by Jing Li, Aerxin Mulatibieke, Shuyuan Liu, Yelixiati Adelibieke, Chen Dai, Suolinge Chahan, Huayun Chen
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Background: This study investigated the diagnosis value of phospholipase A2 receptor autoantibodies (PLA2R-AB) for idiopathic membranous nephropathy (IMN).
Methods: Patients with IMN, lupus nephritis, hepatitis B virus-associated nephropathy and IgA nephropathy and healthy participants were included. Receiver operating characteristics (ROC) curve was plotted for PLA2R-AB to diagnose IMN.
Result: The level of serum PLA2R-AB was significantly higher in patients with IMN than with other MN, and was positively correlated to urine albumin-creatinine ratio and proteinuria in patients with IMN. The area under the ROC curve displaying the performance of PLA2R-AB to diagnose IMN was 0.907 with a sensitivity and specificity of 94.3% and 82.1%, respectively.
Conclusions: PLA2R-AB is a reliable biomarker to diagnose Chinese patients with IMN.
DOI: 10.7754/Clin.Lab.2022.220832
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