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Background: Immature platelet fraction (IPF) is a new hematological parameter. Although its value in predicting the severity and mortality of sepsis patients has been shown, no study has assessed whether IPF can predict sepsis-associated acute kidney injury (S-AKI). Thus, this study aimed to analyze the predictive value of IPF in the occurrence and mortality of S-AKI.
Methods: Sepsis patients from the intensive care unit were screened and divided into S-AKI (n = 53) and non-S-AKI (n = 71) groups. IPF values were calculated by using the CDR mode of the BC-6800Plus hematology analyzer (Mindary, Shenzhen, China). Relevant data, such as serum creatinine (Scr) and uric acid (UA) levels, of the patients were obtained through the hospital information-management system.
Results: The sepsis patients with S-AKI had lower high-density lipoprotein (HDL) levels, higher IPF values, higher Scr, UA, C-reactive protein (CRP), and procalcitonin (PCT) levels, and higher SOFA and APACHE Ⅱ scores than the non-S-AKI patients (p < 0.05). IPF value was found correlated with Scr, HDL, CRP, and PCT levels and APACHE Ⅱ score but not with age, UA level, urine output in 24 hours, or SOFA score. Multivariate logistic regression analysis suggested that IPF, UA, and HDL are independent risk factors for S-AKI. The area under the curve (AUC) of IPF in the identification of S-AKI incidence was found superior to the AUC of UA and 1/HDL with a cutoff value of 12.15. However, IPF was not found associated with mortality in S-AKI.
Conclusions: IPF can serve as a biomarker to predict S-AKI in sepsis patients.
DOI: 10.7754/Clin.Lab.2022.220930
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