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Serum Erythropoietin Levels in Pediatric Patients with ß-Thalassemia/Hemoglobin E by Nara Paritpokee, Viroj Wiwanitkit, Narudee Bhokaisawan, Chaiyaporn Boonchalermvichian, Paungpayom Preechakas

Presently, the assays for serum erythropoietin (EPO) seem valuable tools for clinical research, but their roles in routine clinical practice remain undefined. Some studies mentioned that serum EPO measurements, which are now easily and reliably performed, should be used in monitoring the therapy of β-thalassemia major. Here, we report our experience in the determination of serum EPO in children with β-thalassemia/Hb E and also compared the results with those in hemoglobin E trait, β-thalassemia/Hb E as well as healthy non-anemic controls of similar age. Fiftyfive transfusion-dependent β-thalassemia./Hb E, fifteen hemoglobin E trait, five β-thalassemia trait cases and twentyfive controls were studied for their serum EPO levels. The mean (S.D.) EPO concentrations were 19.94 (17.40) U/L for the controls, 16.13 (8.47) U/L for the hemoglobin E trait, 24.40 (8.20) U/L for the β-thalassemia trait and 372.19 (432.04) U/L for the β-thalassemia/Hb E cases. The mean EPO concentration for the normal controls was near to that of the hemoglobin E trait (p = 0.06) and B-thalassemia trait (p = 0.25) but eighteen times less than that for the β-thalassemia major cases (p < 0.0005). (Clin. Lab.2002;48:631-634)

DOI: Clin. Lab. 2002;48 :631-634