Abstract
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Three Novel Variants of t(8;21) and Classical t(8;21) Translocation in Acute Myeloid Leukemia
by Zhaohua Zhang, Piaoyan Zhang, Suipeng Chen, Xiao Feng, Ruqing Yang, Yongshi Zhao, Xinyi Zhou, Qianru Jin, Chuan Sun, Qian Li
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Background: Some studies have discussed adverse prognosis factors of AML with t(8;21) to be closely related to genetic changes.
Method: We reviewed 58 cases of AML in children and adults with t(8;21)(q22;q22) translocation.
Results: Five variant translocation cases were observed: t(8;17;21)(q22;q12;q22) (case 1), t(1;8;21)(q12;q22;q22) (case 2), and t(8;12;21)(q22;p13;q22) (case 3). The translocations were first observed in three children. Case 2 was cured with chemotherapy, and the cut-off date of observation was 120 months. Case 3 relapsed after 1 year (overall survival [OS], 14 months). Patients with AML with t(8;21) variant translocation have different prognoses and require further study. Forty-two of the 58 cases were included in the survival analysis. Cox regression analysis showed that progression-free survival (PFS) was correlated with age group, white blood cell (WBC) count, bone marrow blast ratio, and loss of Y chromosome (-Y). Overall survival (OS) was correlated with age group, WBC count, and -Y. Childhood leukemia with t(8;21) has a better prognosis than adult leukemia. Survival curves were drawn according to age and cytogenetic abnormalities.
Conclusions: Progression-free survival was correlated with age, white blood cell (WBC) count, bone marrow blast ratio, and loss of Y chromosome (-Y). OS was correlated with age group, WBC count, and -Y chromosome. Child-hood leukemia with t(8;21) has a better prognosis than adult leukemia.
DOI: 10.7754/Clin.Lab.2022.220433
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