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Study on Lipid Metabolism and Related Risk Factors in Endometrial Polyps by Jian Ren, Qi Zhou, Ziwen Jiang, Ting Li, Yan Hao

Background: The object of the study was to explore the risk factors for endometrial polyps (EP) by analyzing the clinical characteristics and laboratory findings.
Methods: From January 2019 to June 2020, clinical data from 183 patients treated with gynecological hysteroscopic surgery were collected. Among them were 118 EP cases which were included into the study group. They were divided into four groups by age: Group 1: < 30 years old (9, 7.6%), Group 2: ≥ 30 < 40 years old (62, 52.5%), Group 3: ≥ 40 < 50 years of age (39, 33.1%), Group 4: ≥ 50 years of age (8, 6.8%). The remaining 65 patients with uterine adhesion were used as controls.
Results: Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), hemoglobin (HGB), and uterine volume between the two groups were statistically significant. TC, LDL-C, and uterine volume were identified as independent risk factors for EP, with TC being the most significant. In patients < 40 years of age, HGB, LDL-C, and uterine volume were significantly different, with LDL-C and uterine volume acting as independent risk factors and uterine volume being more significant. There were differences in the overall distribution of blood flow signal ratio in the EP age groups. Menarche occurred significantly earlier in Groups 1, 2, and 3 than in groups 4. Uterine volume was significantly smaller in Group 1 than Group 3. LDL-C and uterine volume had better prediction values for EP. When the uterine volume was 61.65 cm3, the sensitivity was 58.6%, and the specificity was 93.5%.
Conclusions: In clinical practice, attention should be paid to the cholesterol metabolism in EP patients.

DOI: 10.7754/Clin.Lab.2022.220415