Abstract

Background: Both plasma cell myeloma (PCM) and Waldenstrom’s macroglobulinemia (WM) are mature B-cell neoplasms commonly involving bone marrow and usually related to paraproteinemia.
Methods: Secondary WM in a patient with PCM during maintenance therapy has not been previously reported. We herein report the first case of WM arising during maintenance therapy of PCM.
Results: The diagnosis of secondary WM during maintenance therapy of PCM was based on combination of medical history, morphology, flow cytometry, immunofixation electrophoresis, and molecular genetics.
Conclusions: This case highlights the importance of an integrated diagnostic work-up, with an interesting role for morphology and flow immunotyping.

DOI: 10.7754/Clin.Lab.2022.220527