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Russell Body-Like Inclusions in Granulocytes in Remission of Acute Myeloid Leukemia by Rui Zhang, Mei Liu, Fang Cui, Min Shi

Background: Russell bodies are mostly found in pathological plasma cells and have never been reported in other types of cells. Here, we present a rare case of Russell-like bodies in granulocytes from a 65-year-old woman with acute myeloid leukemia (AML) in remission who had been treated with IA chemotherapy.
Methods: The nature and origin of Russell-like bodies were evaluated by Wright-Giemsa staining, tissue biopsy and immunohistochemical staining, serum immunofixation electrophoresis.
Results: The bone marrow aspirate smear revealed many different circular, refractive Russell-like inclusions in the cytoplasm of some myelocytes and metamyelocytes. Tissue biopsy of left waist lesion showed fatty necrosis infiltrated with multifocal lymphocytes, phagocytes, and plasma cells and subcutaneous small focal calcifications. The result of serum immunofixation electrophoresis revealed that the level of IgG was 30.3 g/L (↑) and λ light chain was weakly positive.
Conclusions: Russell body-like inclusions in granulocytes should be noted. It is necessary for further clinical observation and monitoring to determine whether the disease progressed to MM on the basis of serum immuno-fixation electrophoresis.

DOI: 10.7754/Clin.Lab.2022.211252