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Upregulation of Toll-Like Receptors 2, 5, 7, and 9 in the Cervical Epithelial Cells of Iranian Women Infected with High-Risk Human Papilloma Virus by Banafsheh Douzandeh-Mobarrez, Ashraf Kariminik, Mohammad K. Arababadi, Babak Kheirkhah

Background: Toll-like receptors (TLRs) play dual roles against viruses, including defense against the viruses and induction of the viral-related cancers. High risk human papilloma viruses (HPVs) play key roles in induction of HPV-related cancers. The molecules that are upregulated by the high-risk viruses can be considered as the candidate to induce the cancers. This project was designed to evaluate expression of TLR1-9 in the women infected with HPV-high risk genotypes.
Methods: This project was performed on 40 women infected with high-risk HPV genotypes and 40 healthy controls. Infections with HPV-high risk genotypes and relative expressions of TLR1-9 were explored using real-time PCR technique.
Results: Relative expressions of TLR2, TLR5, TLR7, and TLR9 were significantly higher in the HPV-high risk genotype infected participants when compared to non-infected cases.
Conclusions: Due to the results, it appears that TLR2, TLR5, TLR7, and TLR9 are more important than other TLRs in the pathogenesis of cancers in the Iranian women, who are infected with HPV-high risk genotypes.

DOI: 10.7754/Clin.Lab.2022.220120