Abstract

Background: Hepatitis B virus-associated decompensated cirrhosis (HBV-DeCi) has a high risk of short-term mortality. However, it is difficult to predict the prognosis of these patients in clinical practice. The present study sought to determine whether red cell distribution width-to-lymphocyte ratio (RLR) is related to adverse outcomes in HBV-DeCi patients.
Methods: One hundred and seventy HBV-DeCi patients were recruited for the study. The patients were divided into survivor and non-survivor groups according to the 30-day mortality. Multivariate logistic analyses and area under the receiver operating characteristic curve (AUROC) values were used to determine the performance of RLR as a prognostic predictor in HBV-DeCi.
Results: The 30-day mortality of the HBV-DeCi patients was 13.5% (23/170). RLR was higher in the non-survivor group compared with the survivor group. Multivariate analysis identified RLR as an independent factor for mortality in HBV-DeCi patients. The AUROC analysis demonstrated that RLR can be a reliable prognostic biomarker for HBV-DeCi patients.
Conclusions: RLR could be utilized as a short-term prognostic indicator for HBV-DeCi patients.

DOI: 10.7754/Clin.Lab.2022.220229