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Seroprevalence of Anti-Thyroglobulin Antibodies in Korea by Rihwa Choi, Sang Gon Lee, Eun Hee Lee

Background: The appropriate use of the thyroglobulin (Tg) test involves the concurrent measurement of Tg auto-antibodies (Tg Ab) due to the potential for false low or false high Tg due to Tg Ab interference.
Methods: We retrospectively reviewed Tg and Tg Ab test results requested from local clinics and hospitals in Korea between July 1, 2020 and June 30, 2021.
Results: During the study period, 13,811 Tg tests were performed. Among them, 6,769 Tg tests were identified as being repeatedly measured from 2,988 Korean adults. Among the 6,769 performed Tg tests, 2,733 (40.4%) did not have concurrently performed Tg Ab tests. Among the 2,988 subjects, 1,089 (36.4%) had no concurrently measured Tg Ab test results. Among 4,036 Tg results with concurrently measured Tg Ab, 1,045 (25.9%) had positive Tg Ab results, which could interfere with Tg concentration measurements.
Conclusions: The Tg Ab test appears to be underutilized in Korea.

DOI: 10.7754/Clin.Lab.2022.220119