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Plasma Exosomal CXCL7 is a Potential Biomarker for Lung Adenocarcinoma by Wenting Fang, Jianbin You, Qifeng Xu, Yingfeng Jiang, Haizhou Hu, Falin Chen, Liangyuan Chen

Background: Lung cancer is a leading cause of cancer-related death, with lung adenocarcinoma (LUAD) representing the most common subtype. Recently, exosome-based biomarkers have provided new diagnostic approaches for malignancies.
Methods: The differential expression profile of plasma exosomal mRNA was established by high-throughput sequencing, and the expression and diagnostic value of plasma exosomal CXCL7 mRNA and protein in LUAD were studied to evaluate their diagnostic value as tumor biomarkers.
Results: The expression of plasma exosomal CXCL7 mRNA in patients with LUAD was significantly increased (p < 0.01), which had no significant correlation with age, gender, and stage. ROC was used to evaluate the diagnostic value of plasma exosomal CXCL7 mRNA in LUAD patients with AUC = 0.7171. Further analysis signified that the CXCL7 protein of plasma exosomes in LUAD patients was overexpressed, and it was positively correlated with TNM stage and age. The diagnostic value of plasma exosomal CXCL7 in LUAD is better than serum CEA, with an AUC of 0.785, which has higher sensitivity and specificity.
Conclusions: This research suggests that plasma exosomal CXCL7 may become an effective biomarker for early diagnosis of LUAD.

DOI: 10.7754/Clin.Lab.2022.220128