Abstract
|
Association of SARS-CoV-2 IgG Antibody Levels with Clinical/Laboratory Characteristics in COVID-19 Patients: Data from a Turkish Study
by Ridvan Karaali, Harika O. Dinc, Yusuf E. Ozdemir, Zeynep G. Dalar, Ahmet F. Kurt, Ayse N. Aktas, Serhat Sirekbasan, Yesim T. Tok, Mert A. Kuskucu,
Ilker I. Balkan, Bilgul Mete, Gokhan Aygun, Kenan Midilli, Suat Saribas, Nese Saltoglu, Huseyin Cakan, Bekir S. Kocazeybek
|
|
|
Background: COVID-19 causes clinical manifestations ranging from asymptomatic infection to multi-organ failure. It is reported that those with severe disease have higher anti-SARS-CoV-2 antibody titers compared to asymptomatic or mild cases. We evaluated the correlation of antibody responses with laboratory and clinical indicators in COVID-19 patients.
Methods: Seventy-nine male and 66 female patients (mean age: 39) with at least one positive SARS-CoV-2 RT-PCR test and SARS-CoV-2 IgG antibody result after acute infection were included.
Results: Seventy-six (52%), 45 (31%), and 24 (17%) patients had mild, moderate, and severe clinical findings, respectively. Patients with high body mass index and advanced age had significantly more severe disease (p < 0.001). A significant correlation was found between the increase in lymphopenia, C-reactive protein, ferritin, D-dimer, and lactate dehydrogenase and the severity of clinical findings (p = 0.0001). SARS-CoV-2 IgG antibody test was positive in 128 (88.3%) patients. A significant correlation was found between disease severity and antibody levels in the comparison of all groups (p < 0.001).
Conclusions: Long-term monitoring of immune responses will be required to determine the appropriate time for the administration of new vaccines.
DOI: 10.7754/Clin.Lab.2021.211230
|
