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Relationship between Changes in Drug Score, D-Glucaric Acid Excretion, and γ-Glutamyltransferase and ß-Glucuronidase Serum Activities during Anticonvulsant Treatment by Jesús Hermida, M Pilar Fernández and J Carlos Tutor

The purpose of this study was to investigate the relationship of changes in the enzyme-inducing anticonvulsant daily dosage (drug score) to variations in urinary D-glucaric acid excretion and γ-glutamyltransferase and β-glucuronidase serum activities. These biochemical determinations were carried out before and after a mean period of 5.0 years in 16 adult epileptic patients (8 men and 8 women) treated with phenobarbital, phenytoin and/or carbamazepine and with a good therapeutic compliance. A signifïcant correlation between D-glucaric acid excretion and drug score vvas obtained (r = 0.508, p < 0.001). When the interindividual variation was diminished by assessing the changes of these variables in the same subjects, the correlation was better (r = 0.836, p < 0.001). However, a statistical significance was not attained between the γ-glutamyltransferase or β-glucuronidase and drug score changes. Therefore the urinary excretion of D-glucaric acid appears to be more sensitive to changes in anticonvulsant drug score than serum γ-glutamyltransferase and β-glucuronidase. (Clin. Lab. 2002;482415-419

DOI: Clin. Lab 2002;48:415-419