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Rh Phenotype and Allele Frequencies Among 88,856 Patients in China by Yongqiang Shan, Yaohua Xu, Chunhong Du, Haitao Huang, Yuan Zhang

Background: This study was performed to provide information on the frequencies of Rh antigens, alleles, and phenotypes from our region in Tianjin, China.
Methods: This observational study was conducted on patients from January 2018 to March 2021 using a fully automated system for ABO and Rh typing of blood cells. The phenotypes of C, c, E, and e were detected by the slide method. The data were collected and calculations done to determine the antigen, phenotypes and allele frequencies.
Results: Four hundred thirty-three cases of Rh (D) negative phenotype were confirmed in 88,856 patients. Of the four Rh antigens (C, c, E, e) that were phenotyped by serological methods, the ā€œeā€ antigen was found to have the highest frequency (99.74%). The most common Rh negative phenotype observed was ccdee, followed by Ccdee. The prevalence of Rh phenotypes ccdEe, CCdee, CcdEe, CCdEe, ccdEE were found to be rare in our population with percentages of 0.0473%, 0.018%, 0.018%, 0.0034%, and 0.0011%, respectively.
Conclusions: Knowledge of red cell antigen phenotype frequencies in a population is helpful in terms of their ethnic distribution. We have determined the prevalence of Rh antigens and Rh phenotypes in China. The Rh blood group distribution in this population was different from that in other populations.

DOI: 10.7754/Clin.Lab.2021.211037