Background: The evaluation of hypothalamic-pituitary-gonadal axis function is essential for girls with pubertal disorders. The laboratory gold standard for evaluating the axis is blood gonadotropin level during gonadotropin-releasing hormone stimulation test. However, these tests need venipuncture and repeated blood collection, which affect the compliance of children and parents.
Methods: Studies were conducted on the basis of a computer-assisted search of the literature published in English using the National Library of Medicine, PubMed, Google Scholar, and Google databases, and published in Chinese core journals.
Results: According to this review, urine collection is non-invasive and convenient. Urine gonadotropin can reflect the average level of blood, which can reflect the HPGA function of girls with pubertal disorders. However, because of the limited sensitivity of LH detection, urine Gn during the GnRH stimulation test cannot replace that of the blood.
Conclusions: It is worth improving the sensitivity of LH detection kits. In the future, perhaps most exciting is replacing blood for evaluating HPGA function in girls with the urine Gn determination in the lab during the GnRH stimulation test.