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Evaluation of Serum MiR-184 and MiR-326 Expression in PCOS Subjects: Correlation with PCOS Related Parameters by Chunyan Gao, Lin Guo, Zhenjuan Jiang, Lijuan Cao

Background: MicroRNA (miRNA) is an endogenous non-coding single-stranded RNA with highly conserved characteristics, which has been proven to regulate gene expression and biological functions of organisms after transcription. Therefore, exploring the differentially expressed miRNAs during the disease process is of great significance for the diagnosis of the disease.
Methods: The focus of this study is to explore the differences in serum expression of miR-184 and miR-326 in polycystic ovary syndrome (PCOS) subjects, and analyze the Pearson’s correlation with PCOS disease characterization parameters. The basic physical characteristics and related biochemical indicators and hormone levels of 60 PCOS subjects and 60 healthy subjects of the same period were tested.
Results: MiR-184 and miR-326 in serum were detected, and it was found that miR-184 and miR-326 in PCOS subjects were significantly increased. Correlation analysis found that miR-184 and miR-326 are positively correlated with body mass index, follicle number, ovarian volume, luteinizing hormone, prolactin, estradiol, progesterone, testosterone, fasting blood glucose, fasting serum insulin, homeostasis of insulin resistance model evaluation, and triglycerides and negatively correlated with high-density lipoprotein.
Conclusions: The study showed that serum miR-184 and miR-326 are highly expressed in PCOS patients and can be used as molecular biomarkers for PCOS diagnosis. They may be involved in the metabolism and reproductive function of PCOS patients.

DOI: 10.7754/Clin.Lab.2021.210823