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The Importance of D-Dimer, Ferritin, CRP and Lymphocyte Values in Determining Mortality in COVID-19 Disease in Turkey by Hatice Topcu, Yunus E. Arik

Background: It is critical to determine the importance of laboratory tests on the mortality of Covid-19 disease. Our aim is to search the effect of D-dimer, C-reactive protein (CRP), ferritin, and lymphocyte count in the algorithm organized by our Ministry of Health in the diagnosis and treatment of Covid-19 on mortality.
Methods: Two hundred forty-five patients admitted to the emergency department (ED) with a diagnosis of Covid-19 pneumonia between March 15, 2020, and May 15, 2020. CRP, D-dimer, ferritin, and lymphocyte count included in the algorithm of the Ministry of Health. The relationship between demographic, clinical, and laboratory characteristics of the patients and their thirty-day mortality was examined.
Results: A statistically significant difference was only found in coronary artery disease between the mortality rates and underlying diseases of the patients included in the study. When the diagnostic contribution of laboratory values to the mortality estimation was evaluated, the areas under the curve were the highest for CRP 0.782 (95% Cl 0.68 - 0.88), ferritin 0.740 (95% Cl 0.60 - 0.88), and D-dimer 0.738 (95% Cl 0.58 - 0.89).
Conclusions: An increased serum CRP, D-dimer, ferritin levels, and low lymphocyte count as shown by Turkish Ministry of Health in Turkey are significant predictors of COVID-19 mortality.

DOI: 10.7754/Clin.Lab.2021.210720