Background: Cardiovascular diseases, as a common cause of hospitalization and death, appear to be connected with ABO blood groups. Following some studies in which the blood groups are found to be associated with the coronary artery disease, the present study investigates the relationship between ABO blood groups and the incidence of acute coronary syndrome (ACS).
Methods: In this study, 360 patients with a diagnosis of ACS were enrolled in a randomized study. The checklist included demographic and anthropometric information as well as cardiovascular risk factors. The blood groups were determined by standard agglutination technique. These patients underwent cardiac echocardiography and coronary angiography (CAG). The obtained data were analyzed by SPSS 23.
Results: It is found that the blood groups O+ and A+ with 31.9% and 29.2%, respectively, had the highest prevalence, and blood group AB- with a prevalence of less than 1% had the lowest prevalence in ACS patients. Even though in this study the frequency of ACS in blood group O was higher than other blood groups, there was no statistically significant relationship between the frequency of ACS and the type of ABO blood group.
Conclusions: There is no meaningful relationship between ABO blood type and the prevalence of the risk factors underlying cardiovascular diseases. Also, there is no statistically significant relationship between ABO blood type and any of the paraclinical parameters. Moreover, it is found that without considering the Rh factor, the blood group O phenotype increases the risk of cardiovascular disease. It also appears to be independent of cardiovascular risk factors.