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Associations of Homocysteine, Procalcitonin, and D-Dimer Levels with Severity and Prognosis of Patients with Multiple Trauma by Wei Tian, Wen Meng

Background: The aim was to explore the associations of plasma D-dimers (D-D), homocysteine (HCY), and procalcitonin (PCT) levels with multiple trauma.
Methods: A total of 116 patients were divided into two groups with severe and mild diseases. After 6 months of follow-up, the group with severe disease was divided into survivor and non-survivor groups. The correlations of APACHE II score and simplified acute physiology score II (SAPS II) with D-D, HCY, and PCT levels were subjected to Spearman’s analysis. The influencing factors for prognosis were studied using logistic regression analysis, and the values of these levels for prognostic evaluation were explored by plotting receiver operating characteristic curves.
Results: After treatment, the group with severe disease had higher levels of D-D, HCY, PCT, APACHE II score, and SAPS II than those of the group with mild disease (p < 0.05). The non-survivor group had significantly higher levels than those of the survivor group (p < 0.05). The levels of 116 patients with multiple trauma had positive correlations with APACHE II score and SAPS II (p < 0.001). The levels were independent risk factors affecting prognosis. Their combination had high diagnostic value for prognostic evaluation.
Conclusions: The combination of plasma D-D, HCY, and PCT levels seems to be a useful index for the early evaluation of severity and prognostic evaluation of patients with multiple trauma.

DOI: 10.7754/Clin.Lab.2021.210525