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Anti-LW Confused with Anti-D: a Case Transfused RhD-positive RBCs and Literature Review by Min Young Lee, Woo In Lee, So Young Kang, Myeong Hee Kim

Background: Anti-LW is rarely identified, and it is known to have little clinical importance. However, it is often difficult to differentiate anti-LW from anti-D.
Methods: Here, we report a case where anti-LW was identified for pretransfusion testing in a patient suspected of having lymphoma.
Results: His blood group was O RhD-positive. Anti-D specificity, weak panreactivity and 2+ reactivity in auto control were shown as a result of antibody identification. The reactions became weaker with DTT-treated RBCs, which confirmed the specificity of an anti-LW. The patient received 8 units of O RhD-positive pRBC before discharge without any transfusion reaction.
Conclusions: In conclusion, anti-LWs may show mimicking specificity of anti-D for antibody identification testing, but their clinical significance is completely different. Therefore, their prompt identification is important.

DOI: 10.7754/Clin.Lab.2021.210603