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Prevalence of Serum Specific Antibodies to TORCH Agents in a Cohort of Children Using DiaSorin “Flash” Chemiluminescence Technology by Madalina A. Bordea, Gabriel Samasca, Cornel Aldea, Iulia Lupan, Carmen Costache

Background: Our study was undertaken to detect the prevalence of serum specific antibodies to TORCH agents in children by establishing the presence of the specific IgM antibodies with DiaSorin “Flash” chemiluminescence technology.
Materials and Methods: A total of 804 blood samples were collected for the detection of the Toxoplasma IgM; 2,048 cases were collected for CMV IgM, and 337 cases were collected for HSV-1/2 IgM, over a period of 9 months (from January 2019 to September 2019).
Results: In our cohort, a total of 103 samples (12.8%) were found to be seropositive for Toxoplasma, 1,551 samples (75.7%) were positive for CMV and 174 samples (51.6%) were positive for the HSV-1/2 infections. The perinatal CMV infection was observed in 11.9% of the patients with positive serology for CMV.
Conclusions: The routine antenatal screening with chemiluminescence technology should be recommended in general population to avoid congenital malformations, as long as the prevalence of serum specific antibodies to TORCH agents is high and seropositivity rate increases with age.

DOI: 10.7754/Clin.Lab.2021.201219