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Does Hepatitis B Virus Affect the Coagulation Parameters for HBV-Related Decompensated Cirrhosis? by Yanhua Yi, Donglin Zhu, Xiaojie Li, Zhizhi Xie, Bangqiang Xie, Yun Xi, Changzhi Xu

Background: To evaluate the effect of the hepatitis B virus (HBV) on the coagulation parameters in patients with hepatitis B virus-related decompensated cirrhosis (HBV-DeCi).
Methods: A retrospective analysis was conducted on the medical records of 112 patients with HBV-DeCi. Baseline clinical and laboratory characteristics were retrieved. Subjects were subdivided into 3 groups. Group I: 22 cases of hepatitis B were HBsAg, HBeAg, and HbcAb positive; Group II: 67 patients were HBsAg, HBeAb, and HbcAb positive; Group III: 23 patients were HBsAb, HBeAb and HbcAb positive. The coagulation indicators, such as prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), and international normalized ratio (INR, a method to standardize reporting of the PT, using the formula, INR = (PTpatient/PTcontrol)ISI) of each groups were analyzed, The correlation between the characteristics of coagulation function and the type of hepatitis infection were studied.
Results: The FIB values of Group I and II were lower than those of Group III, and Group I had significantly longer TT compared to Group III.
Conclusions: In patients with HBV-DeCi, hepatitis B virus has an effect on coagulation parameters; therefore, antiviral treatment must be carried out as soon as possible.

DOI: 10.7754/Clin.Lab.2020.201211