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NF-kB Expression, Comparison of Intestinal Flora, Inflammation and Adiponectin and Clinical Significance in Prostate Cancer Patients by Yongtao Yu, Xiang Hong

Background: The aim was to compare the changes in nuclear factor kappa-B (NF-κB) expression, intestinal flora, inflammatory indexes, and adiponectin (ADPN) between prostate cancer patients complicated with metabolic syndrome (MS) and those without MS and to analyze their clinical significance.
Methods: A total of 90 patients with prostate cancer diagnosed in our hospital from May 2018 to November 2019 were selected and divided into MS group (observation group, n = 45) and no MS group (control group, n = 45). Then the patients’ general data, including age, body mass index (BMI), and blood pressure, were collected. Thereafter, the prostate volume was measured, blood triglyceride (TG), inflammatory indexes, fasting plasma glucose (FPG), fasting insulin (FINS), and ADPN were detected. In addition, the postoperative pathological Gleason score, pathological T (pT) stage, and pelvic lymph node metastasis were compared, and the relationship and influencing factors were explored.
Results: There were no significant differences in age and blood pressure between the observation group and the control group. 1) The observation group had a significantly higher BMI, remarkably more TGs, and a notably larger prostate volume than the control group (p < 0.05). 2) The expression rate of NF-κB in the specimens in the observation group was markedly higher than that in the control group, and the difference was statistically signifi-cant (p < 0.05). 3) The total bacterial load in the observation group was obviously larger than that in the control group, in which the levels of Bifidobacteria and Lactobacilli (two types of probiotics) in the former were significantly lower than those in the latter, but the levels of Escherichia coli, Helicobacter pylori, Streptococci, and Staphylococci (harmful bacteria) in the former were evidently higher than those in the latter (p < 0.05). 4) The levels of inflammatory factors, including catabolite activator protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), in the peripheral blood in the observation group were markedly higher than those in control group (p < 0.05). 5) The observation group had distinctly higher levels of FINS and FPG and an evidently lower level of ADPN than the control group, showing statistically significant differences (p < 0.05). 6) The postoperative pathological Gleason score, the number of patients in pT3 - 4 stages, and the number of patients with pelvic lymph node metastasis in the observation group were remarkably higher and larger than those in the control group (p < 0.05).
Conclusions: The metabolic indexes such as blood lipid in prostate cancer patients complicated with MS are higher than those in prostate cancer patients without MS, and the degree of malignancy in the former is higher, suggesting that MS may promote the development of prostate cancer.

DOI: 10.7754/Clin.Lab.2020.200938