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A Rare Case of Cutaneous Intravascular NK/T-Cell Lymphoma by Yuanyuan Jia, Dong Pei, Xueqi Yang, Wei Min, Linyi Song

Background: Cutaneous intravascular NK/T cell lymphoma (CIVNKTC) is a rare form of extranodal non-Hodgkin’s lymphoma with its unique histological and immunophenotypic characteristics.
Methods: We report a case presenting with an over 2-month history of nodules on the extremities and trunk with intermittent fever. Skin biopsy was taken from the patient and a histopathological examination was made from the material.
Results: The histopathological examination showed some expanding vessels filled with atypical lymphoid cells in the dermis and subcutaneous tissue. The tumor cells had large nuclei and one or two small nucleoli, with the expression of CD3, cytotoxic protein, and Epstein-Barr virus (EBV)–encoded messenger RNAs (EBER), and without the expression of tumor cytokeratin (CK), CD20, CD79A, CD4, and CD8. After being diagnosed as CIVNKTC and treated with a CHOP regimen 6 times, the patient died of this disease 1 year later.
Conclusions: The clinical course is dangerous and the prognosis is extremely poor.

DOI: 10.7754/Clin.Lab.2020.201110