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Correlation between Platelet-to-Neutrophil Ratio and Mortality in Patients with HBV-Associated Decompensated Cirrhosis by Jianping Wu, Xiaojie Zhang, Xiaopeng Zhang, Xia He, WeiLin Mao

Background: This study investigated whether platelet-to-neutrophil ratio (PNR) can predict short-term mortality in patients with HBV-associated decompensated cirrhosis (HBV-DeCi).
Methods: We retrospectively analyzed 121 HBV-DeCi patients. Multivariate logistic regression analysis was applied to identify predictors of mortality. Receiver operating characteristic curves were used to determine prognostic accuracy.
Results: Thirteen HBV-DeCi patients (10.7%) died at 30 days after admission. PNR was significantly lower in survivors compared with non-survivors and was negatively correlated with Model for End-Stage Liver Disease (MELD) score. Both MELD score and PNR were independent predictors for 30-day mortality.
Conclusions: The present findings suggest that PNR may be a useful biomarker for predicting mortality in HBV-DeCi patients and could have potential for clinical application.

DOI: 10.7754/Clin.Lab.2020.201001