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Evaluation of Candidate SNPs for Type 2 Diabetes Mellitus in Tohid Hospital of Sanandaj by Fatemeh Keshavarzi, Rasoul Nasiri Kalmarzi, Azad Fattahy Rad

Background: The allele frequency of 4 SNPs was evaluated in patients with type 2 diabetes mellitus (T2DM) and compared with healthy controls who had records in Tohid Hospital of Sanandaj.
Methods: This case-control study was performed on 100 T2DM patients and 100 healthy controls with matched gender and age. After DNA extraction, allele frequency of 4 variant genotypes was evaluated using Tetra-Arms technique. Then, logistic regression analysis was used to calculate the odds ratio. Data analysis was done using SPSS 20 software and the level of significance was less than 0.05.
Results: There were no significant relationships between CASQ1 rs2275703A/C and CTLA4 rs231775A/G polymorphisms and T2DM mellitus in the studied population. Also, CC and CT genotypes of the TCF7L2 rs7903146 C/T polymorphism confirmed a T2DM risk factor in the studied population. At the ATF6 rs2070150 C/G polymorphisms, the frequency of GC allele was higher in the control group than in the patient group, and these differences were also statistically significant at the level of alleles in the experimental and control groups.
Conclusions: The CC and CT genotype of TCF7L2 rs7903146 polymorphism and GC genotype of ATF6 rs207015 were the risk factor for T2DM in this population.

DOI: 10.7754/Clin.Lab.2020.200910