Abstract
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Application Value of Lipoprotein-Associated Phospholipase A2 Expression Level in Evaluating the Risk of Major Bleeding in Gestational Diabetes
by Ying Li, Jinjing Wang, Kai Wang, Tao Peng, Hongyan Liu, Hong Zheng, Qiong Hu
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Background: Studies have shown that obesity and lipid metabolism disorders can lead to increased Lp-PLA2 ac-tivity in the body. However, few studies have reported the correlation between Lp-PLA2 and postpartum hemorrhage in pregnant women with GMD.
Methods: Clinical data was collected from 43 pregnant women with gestational diabetes combined with postpartum hemorrhage and 50 pregnant women with postpartum diabetes without postpartum bleeding during the same period. Lp-PLA2 expression levels in the serum of pregnant women in both groups were detected. The predictive value of Lp-PLA2 expression level for postpartum hemorrhage was clarified.
Results: (1) From 20w to 32w pregnancy, the serum Lp-PLA2 levels of pregnant women in both groups showed a gradual increasing trend. (2) The serum Lp-PLA2 level of the pregnant women in the research group was significantly higher (p < 0.001). (3) Binary logistic regression analysis shows that Lp-PLA2 level has a good correlation with postpartum major bleeding. (4) Comparing of Lp-PLA2 levels in different gestational weeks with respect to its efficacy for predicting postpartum hemorrhage found that the sensitivity and specificity of 24w Lp-PLA2 levels are higher than other gestational weeks, and the area under the 24w parameter curve (0.955) > 32w area under the parameter curve (0.952) > area under the 20w parameter curve (0.940) > area under the 28w parameter curve (0.887). (5) The birth weight of the newborn in the research group was significantly heavier (p < 0.001).
Conclusions: Dynamic monitoring of the expression level of Lp-PLA2 in the serum of pregnant women can predict the risk of postpartum hemorrhage in pregnant women at an early stage and help optimize the rescue plan for postpartum hemorrhage.
DOI: 10.7754/Clin.Lab.2020.200906
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