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Protective Role of CTRP3 and CTRP9 in the Development of Gestational Diabetes Mellitus by Ling Xia, Huijuan Zhang, Qiang Shi, Xueling Zhang, Chongqiang Wang, Guozhi Lin

Background: The current study aims to detect the expression of C1q tumor necrosis factor related protein 3 (CTRP3) and CTRP9 in serum of patients with gestational diabetes mellitus (GDM), so as to provide basis for the prevention and treatment of GDM.
Methods: A total of 129 pregnant women with GDM were selected, and 130 pregnant women with normal glucose metabolism were selected as the control group. The serum levels of CTRP3 and CTRP9 were detected by enzyme-linked immunosorbent assay (ELISA). Pearson’s correlation assay was used to compare the correlation between the level of serum CTRP3 and CTRP9 and clinical indicators. ROC analysis was performed to evaluate the diagnostic value of serum CTRP3 and CTRP9.
Results: Our data showed that the levels of CTRP3 and CTRP9 in the GDM group were lower than those in the control group, while body mass index (BMI), hemoglobin A1C (HbA1c), hypersensitive C-reactive protein (hs-CRP), IL-6, TNF-α, fasting plasma glucose (FPG), fasting insulin (FINS), and homeostasis model assessment of insulin resistance (HOMA-IR) were higher than those in the control group. Pearson’s correlation assay showed that serum CTRP3 and CTRP9 was negatively correlated with FPG, FINS, and HOMA-IR. The AUC of the combined diagnosis of GDM was better than that of the single index (0.936 (0.868 - 0.996)), including CTRP3, CTPR9 and FPG.
Conclusions: Altogether, low expression of serum CTRP3 and CTRP9 in patients with GDM was negatively correlated with IR and may shed light on revealing the pathogenesis of GDM.

DOI: 10.7754/Clin.Lab.2020.200247