Background: The present study aims to analyze the serum level of glucose 6-phosphate isomerase (GPI) in patients with knee osteoarthritis (KOA) and evaluate its value in the diagnosis of KOA.
Methods: One hundred patients with confirmed KOA were selected and 100 healthy people in the same period were selected as the control group. ELISA assay was performed to detect the serum GPI level of the subjects. The concentrations of GPI were also analyzed according the severity of KOA. Pearson’s correlation was used to analyze the correlation between serum GPI and clinical index in diagnosing KOA.
Results: We showed novel data that the concentration of GPI in KOA patients was significantly enhanced compared to controls. Furthermore, the concentration of GPI was highest in the severe group, followed by that in moderate group and mild group. Pearson’s correlation assay indicated a positive correlation between serum GPI and the severity of KOA. Meanwhile, a positive correlation was identified between serum GPI concentration and C-reactive protein (CRP) as well as erythrocyte sedimentation rate (ESR) in KOA patients. Receiver operating characteristic (ROC) analysis showed that serum GPI could screen KOA patients from controls.
Conclusions: Collectively, elevated serum GPI concentration contributed to the progression of KOA, and targeting GPI may be useful for the therapy of KOA.