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Diagnostic Value of Serum Long-Chain Noncoding RNA KCNQ1OT1 in Airway Remodeling in Children with Bronchial Asthma by Chenna Gu, Haoran Wang, Shanshan Yang

Background: The current study aims to investigate the clinical value of serum long non-coding RNA (lncRNA) KCNQ1OT1 in airway remodeling in children with bronchial asthma.
Methods: Serum and clinical data of 58 children with bronchial asthma were collected and divided into remodeling group and non-remodeling group. Twenty children with respiratory inflammatory diseases were selected as a control group. Real-time fluorescence quantitative PCR (RT-PCR) was used to detect the expression of serum lnc-RNA KCNQ1OT1. The relationship between serum lncRNA KCNQ1OT1 and asthma remodeling was also analyzed.
Results: The expression level of serum lncRNA KCNQ1OT1 in the remodeling group was higher than that in the non-remodeling group and the control group, and the difference was statistically significant. In the remodeling group, serum lncRNA KCNQ1OT1 was significantly correlated with the thickness of bronchial mucosal reticular basement membrane and the number of fibroblasts. Receiver operating characteristic curve (ROC) analysis showed that serum lncRNA KCNQ1OT1 could differentiate non-remodeling group from remodeling group.
Conclusions: Serum lncRNA KCNQ1OT1 can predict the occurrence of airway remodeling in children with bronchial asthma, thereby initiating early intervention and treatment of airway inflammation.

DOI: 10.7754/Clin.Lab.2019.190819