Abstract
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Unexplained Late-Onset Hemolytic Jaundice Preceded by High Fetal Hemoglobin Level in an Extremely Low Birth Weight Infant
by GoEun Kwon, Aya Okahashi, Nobuhiko Nagano, Chihiro Nozaki, Erina Nakahara, Kazumasa Fuwa, Hiroshi Yagasaki, Hitoshi Kanno, Ichiro Morioka
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Background: Preterm infants sometimes have transient late-onset hemolytic jaundice; however, the etiology has yet to be determined.
Case presentation: In our case, fetal hemoglobin (HbF) level increased significantly to 100% at 23 days of age. Levels of methemoglobin and carboxyhemoglobin also increased to 2.9% and 3.5%, respectively, following the elevated HbF level. At 26 days, hemolytic jaundice developed. No abnormality of red blood cell membranes and enzyme activities was found.
Conclusions: The etiology of late-onset hemolytic jaundice in preterm infants may associate with an impaired switching from HbF to adult hemoglobin (HbA) or reverse switching from HbA to HbF.
DOI: 10.7754/Clin.Lab.2019.190625
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