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Association between Peripheral CD19+ B Cells and Reproductive Outcome in Women with Recurrent Implantation Failure by Weiyan Tu, Yangyang Li, Qiuhong Ding, Liuliu Wang, Sophia T. Frempong, Jiali Ruan, Xiaowen Tong, Shihua Bao

Background: To investigate the roles of T, B, and natural killer (NK) cells in pregnancy outcome of women with recurrent implantation failure (RIF).
Methods: This retrospective cohort study enrolled 196 patients with RIF. Peripheral lymphocyte subsets were measured before and during pregnancy. The relationship between pregnancy outcome and level of lymphocytes was analyzed.
Results: Peripheral CD19+ B cells in women who experienced miscarriage were significantly lower than those who subsequently had live birth. After adjusting for potential confounders in the multiple logistic regression models, each 1% increment in the peripheral CD19+ B cells before pregnancy [odds ratio (OR): 0.93] and during early pregnancy (OR: 0.83) was associated with a significantly decreased risk of miscarriage (p < 0.05). The risk of mis-carriage in patients with ≥ 15% CD19+ B cells before and during pregnancy was 39% and 21% lower, respectively, than in their counterparts with < 15% CD19+ B cells. The association between CD19+ B cells and the risk of miscarriage was nonlinear.
Conclusions: Measurement of peripheral CD19+ subsets may help predict the pregnancy outcome in women with RIF.

DOI: 10.7754/Clin.Lab.2019.190510